Postdoc GAO Xinjiao

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Postdoc

GAO Xinjiao (高新娇)

(+86) 0551-3607821

(+86) 0551-3607821

gaox@@ustc.edu.cn
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Bioinformatics and Chemical Biology

Numerous proteins temporally and spatially have important roles in intracellular transport or cell division. Kinesins are a family of molecular motor proteins that power cargo movements on microtubules using ATP. As the most important post-translational modification of proteins, phosphorylation plays essential roles in all aspects of biological processes. We focus on chemical biological studies of kinesins and kinases over the past 16 years, which have allowed the development of specific chemical inhibitors to probe the precise functions of individual motor proteins and kinases in space and time. Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity, efficacy/potency, metabolic stability, and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials.

Education and research experience
2001.09-2005.07: School of Food Science and Engineering, HeFei University of Technology Major: Biotechnology, Degree: Bachelor of Science  
2005.07-2006.08: School of Life Sciences, University of Science and Technology of China, Bioinformatics researcher
2006.09-2011.06: School of Life Sciences, University of Science and Technology of China Major: Bioinformatics and Chemical Biology, Degree: Ph.D.  
2011.06-present: Hefei National Laboratary for Physical Science at the micro-scale, University of Science and Technology of China, Post-doctoral researcher

Research Interests
Bioinformatics and Chemical Biology; Kinetochore and Mitosis; Virtual screening on mitotic kinases & motor proteins; Molecular dynamics analysis; Genome instability and cancer.

主要在研课题:

1. 国家自然科学基金青年项目《基于高特异性TTK激酶小分子探针筛选的细胞有丝分裂激酶调控网络的研究》2014-2016
2. 中国博士后科学基金《TTK激酶调控有丝分裂的计算与化学生物学研究》2011
3. 中国科学技术大学青年创新基金《ACAP4调控细胞迁移的化学生物学研究》2011

Selected Publications (# equal contribution )

  1. Gao, X., Jin, C., Ren, J., Yao, X., and Xue, Y. (2008). Proteome-wide prediction of PKA phosphorylation sites in eukaryotic kingdom. Genomics 92, 457-463.
  2. Gao, X., Jin, C., Xue, Y., and Yao, X. (2008). Computational analyses of TBC protein family in eukaryotes. Protein and peptide letters 15, 505-509.
  3. Ding, X., Yan, F., Yao, P., Yang, Z., Wan, W., Wang, X., Liu, J., Gao, X., Abrieu, A., Zhu, T., Zhang, J., Dou, Z., and Yao, X. (2010). Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin. Cell research 20, 1386-1389.
  4. Yan, M., Chu, L., Qin, B., Wang, Z., Liu, X., Jin, C., Zhang, G., Gomez, M., Hergovich, A., Chen, Z., He, P., Gao, X., and Yao, X. (2015). Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosis. Scientific reports 5, 10449.
  5. Zhao, X., Wang, D., Liu, X., Liu, L., Song, Z., Zhu, T., Adams, G., Gao, X., Tian, R., Huang, Y., Chen, R., Wang, F., Liu, D., Yu, X., Chen, Y., Chen, Z., Teng, M., Ding, X., and Yao, X. (2013). Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation. Proceedings of the National Academy of Sciences of the United States of America 110, 11023-11028.
  6. Zhu, T., Dou, Z., Qin, B., Jin, C., Wang, X., Xu, L., Wang, Z., Zhu, L., Liu, F., Gao, X., Ke, Y., Wang, Z., Aikhionbare, F., Fu, C., Ding, X., and Yao, X. (2013). Phosphorylation of microtubule-binding protein Hec1 by mitotic kinase Aurora B specifies spindle checkpoint kinase Mps1 signaling at the kinetochore. The Journal of biological chemistry 288, 36149-36159.
  7. Liu, Z., Cao, J., Gao, X., Ma, Q., Ren, J., and Xue, Y. (2011). GPS-CCD: a novel computational program for the prediction of calpain cleavage sites. PloS one 6, e19001.
  8. Liu, Z., Cao, J., Gao, X., Zhou, Y., Wen, L., Yang, X., Yao, X., Ren, J., and Xue, Y. (2011). CPLA 1.0: an integrated database of protein lysine acetylation. Nucleic acids research 39, D1029-1034.
  9. Liu, Z., Cao, J., Ma, Q., Gao, X., Ren, J., and Xue, Y. (2011). GPS-YNO2: computational prediction of tyrosine nitration sites in proteins. Molecular bioSystems 7, 1197-1204.
  10. Liu, Z., Ma, Q., Cao, J., Gao, X., Ren, J., and Xue, Y. (2011). GPS-PUP: computational prediction of pupylation sites in prokaryotic proteins. Molecular bioSystems 7, 2737-2740.
  11. Ren, J., Gao, X., Liu, Z., Cao, J., Ma, Q., and Xue, Y. (2011). Computational analysis of phosphoproteomics: progresses and perspectives. Current protein & peptide science 12, 591-601.
  12. Ren, J., Jiang, C., Gao, X., Liu, Z., Yuan, Z., Jin, C., Wen, L., Zhang, Z., Xue, Y., and Yao, X. (2010). PhosSNP for systematic analysis of genetic polymorphisms that influence protein phosphorylation. Molecular & cellular proteomics : MCP 9, 623-634.
  13. Ren, J., Liu, Z., Gao, X., Jin, C., Ye, M., Zou, H., Wen, L., Zhang, Z., Xue, Y., and Yao, X. (2010). MiCroKit 3.0: an integrated database of midbody, centrosome and kinetochore. Nucleic acids research 38, D155-160.
  14. Ren, J., Wen, L., Gao, X., Jin, C., Xue, Y., and Yao, X. (2008). CSS-Palm 2.0: an updated software for palmitoylation sites prediction. Protein engineering, design & selection : PEDS 21, 639-644.
  15. Ren, J., Wen, L., Gao, X., Jin, C., Xue, Y., and Yao, X. (2009). DOG 1.0: illustrator of protein domain structures. Cell research 19, 271-273.
  16. Xue, Y., Gao, X., Cao, J., Liu, Z., Jin, C., Wen, L., Yao, X., and Ren, J. (2010). A summary of computational resources for protein phosphorylation. Current protein & peptide science 11, 485-496.
  17. Xue, Y., Liu, Z., Cao, J., Ma, Q., Gao, X., Wang, Q., Jin, C., Zhou, Y., Wen, L., and Ren, J. (2011). GPS 2.1: enhanced prediction of kinase-specific phosphorylation sites with an algorithm of motif length selection. Protein engineering, design & selection : PEDS 24, 255-260.
  18. Xue, Y., Liu, Z., Gao, X., Jin, C., Wen, L., Yao, X., and Ren, J. (2010). GPS-SNO: computational prediction of protein S-nitrosylation sites with a modified GPS algorithm. PloS one 5, e11290.
  19. Xue, Y., Ren, J., Gao, X., Jin, C., Wen, L., and Yao, X. (2008). GPS 2.0, a tool to predict kinase-specific phosphorylation sites in hierarchy. Molecular & cellular proteomics : MCP 7, 1598-1608.
  20. Zhu, M., Wang, F., Yan, F., Yao, P.Y., Du, J., Gao, X., Wang, X., Wu, Q., Ward, T., Li, J., Kioko, S., Hu, R., Xie, W., Ding, X., and Yao, X. (2008). Septin 7 interacts with centromere-associated protein E and is required for its kinetochore localization. The Journal of biological chemistry 283, 18916-18925.