Professor YAO Xuebiao

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Professor

YAO Xuebiao (姚雪彪)

Cheung Kong Scholar

(+86) 0551-3607141

(+86) 0551-3607141

yaoxb@@ustc.edu.cn
(-@@- change to @)

Cellular Dynamics and Chemical Biology

Dr. Xuebiao Yao received his Ph.D. from University of California at Berkeley under Professor John Forte’s supervision in 1995, and pursued a postdoctoral fellowship at the Ludwig Institute for Cancer Research with Professor Don Cleveland before joining the faculty of the University of Wisconsin-Madison as an Assistant Professor in 1998. He was selected as a Chueng Kong Scholar of the Ministry of Education and received an Outstanding Young Scientist Award from Natural Science Foundation of China in 1999. Dr. Yao built the Laboratory of Cellular Dynamics in the University of Science & Technology in 2000 and became the Principal Investigator for the State-sponsored Key Basic Science project titled “Regulatory protein interacting networks underlying cell division” in 2002. Dr. Yao’s research interest is centered on the molecular mechanisms underlying cellular plasticity and dynamics. Using kinetochore as a model system, his research team has identified several important kinetochore interacting networks and pathways essential for accurate chromosome segregation. Among many affiliated responsibilities, Dr. Yao serves as an Associate Editor of Journal of Molecular & Cell Biology, and board members of Journal of Biological Chemistry and Cell Research.

Education and research experience  
1980-1984: B.S., Jiangxi College of Chinese Medicine, China  
1991-1995: Ph.D., University of California-Berkeley, USA  
1995-1997: Research Associate, University of California-San Diego, USA  
1997-1999: Assistant Professor, University of Wisconsin-Madison, USA  
2000-2003: Visiting Research Professor, University of California-Berkeley, USA  
2003-2008: Georgia Cancer Coalition Eminent Scholar, USA  
1999-present: Professor of Cell Biology, University of Science & Technology of China  
2008-present: Director, Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, China

Research Interests
Cellular Dynamics and Chemical Biology of cell division and migration in health and diseases

主要在研课题:
1. 国家自然科学基金重大国际合作项目:组蛋白的修饰调控与着丝粒可塑性研究
2. 国家自然科学基金重点项目:PLK1-ACAP4-Ezrin信号轴调控细胞极性形成与维系的分子机制研究
3. 中国科学技术大学创新团队培育基金:"细胞动力学与化学生物学"

Selected Publications

  1. Mo, F., Zhuang, X., Liu, X., Yao, P.Y., Qin, B., Su, Z., Zang, J., Wang, Z., Zhang, J., Dou, Z., Tian, C., Teng, M., Niu, L., Hill, D.L., Fang, G., Ding, X., Fu, C., and Yao, X. (2016). Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation. Nature chemical biology 12, 226-232.
  2. Dou, Z., Liu, X., Wang, W., Zhu, T., Wang, X., Xu, L., Abrieu, A., Fu, C., Hill, D.L., and Yao, X. (2015). Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment. Proceedings of the National Academy of Sciences of the United States of America 112, E4546-4555.
  3. Zhao, X., Wang, D., Liu, X., Liu, L., Song, Z., Zhu, T., Adams, G., Gao, X., Tian, R., Huang, Y., Chen, R., Wang, F., Liu, D., Yu, X., Chen, Y., Chen, Z., Teng, M., Ding, X., and Yao, X. (2013). Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation. Proceedings of the National Academy of Sciences of the United States of America 110, 11023-11028.
  4. Yao, X., Li, D., and Pei, G. (2013). In focus: molecular and cell biology research in China. Nature reviews Molecular cell biology 14, 600-606.
  5. Xia, P., Wang, Z., Liu, X., Wu, B., Wang, J., Ward, T., Zhang, L., Ding, X., Gibbons, G., Shi, Y., and Yao, X. (2012). EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis. Proceedings of the National Academy of Sciences of the United States of America 109, 16564-16569.
  6. Tao, Y., Jin, C., Li, X., Qi, S., Chu, L., Niu, L., Yao, X., and Teng, M. (2012). The structure of the FANCM-MHF complex reveals physical features for functional assembly. Nature communications 3, 782.
  7. Chen, J., Yao, Y., Gong, C., Yu, F., Su, S., Chen, J., Liu, B., Deng, H., Wang, F., Lin, L., Yao, H., Su, F., Anderson, K.S., Liu, Q., Ewen, M.E., Yao, X., and Song, E. (2011). CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer cell 19, 541-555.
  8. Ding, X., Yan, F., Yao, P., Yang, Z., Wan, W., Wang, X., Liu, J., Gao, X., Abrieu, A., Zhu, T., Zhang, J., Dou, Z., and Yao, X. (2010). Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin. Cell research 20, 1386-1389.
  9. Jiang, K., Wang, J., Liu, J., Ward, T., Wordeman, L., Davidson, A., Wang, F., and Yao, X. (2009). TIP150 interacts with and targets MCAK at the microtubule plus ends. EMBO reports 10, 857-865.
  10. Fang, Z., Miao, Y., Ding, X., Deng, H., Liu, S., Wang, F., Zhou, R., Watson, C., Fu, C., Hu, Q., Lillard, J.W., Jr., Powell, M., Chen, Y., Forte, J.G., and Yao, X. (2006). Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4. Molecular & cellular proteomics : MCP 5, 1437-1449.
  11. Yao, X., and Forte, J.G. (2003). Cell biology of acid secretion by the parietal cell. Annual review of physiology 65, 103-131.
  12. Yao, X., Zheng Y, Sullivan KF, & Cleveland DW. (2000). CENP-E forms a link between attachment of spindle microtubules to kinetochore and the mitotic checkpoint. Nature Cell Biol. 2, 484-491.