Associate Professor JIN Changjiang

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Associate professor

JIN Changjiang (金长江)

(+86) 0551-3607141

(+86) 0551-3607141

jincj@@ustc.edu.cn
(-@@- change to @)

细胞周期调控和膜泡运输

金长江,博士,副教授,硕士生导师。
2005 年毕业于中国科学技术大学并获生物学博士学位。其后在合肥微尺度物质科学国家实验室从事博士后研究。2009年作为优秀人才引进被聘为中国科学技术大学生 命科学学院副教授。广泛从事了细胞膜与细胞骨架动力学、细胞有丝分裂调控及蛋白质修饰调控的生物学研究。自2003年起,发表SCI 文章20余篇,其中部分刊登在Oncogene, J. Biol. Chem.等国际知名学术期刊上。


主要研究兴趣:
1. 蛋白质翻译后修饰调控
2. 细胞周期调控
3. 膜泡运输

Selected Publications(# equal contribution; * corresponding author )

  1. Yan, M., Chu, L., Qin, B., Wang, Z., Liu, X., Jin, C., Zhang, G., Gomez, M., Hergovich, A., Chen, Z., He, P., Gao, X., and Yao, X. (2015). Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosis. Scientific reports 5, 10449.
  2. Shao, H., Huang, Y., Zhang, L., Yuan, K., Chu, Y., Dou, Z., Jin, C., Garcia-Barrio, M., Liu, X., and Yao, X. (2015). Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation. Scientific reports 5, 12204.
  3. Cao, D., Su, Z., Wang, W., Wu, H., Liu, X., Akram, S., Qin, B., Zhou, J., Zhuang, X., Adams, G., Jin, C., Wang, X., Liu, L., Hill, D.L., Wang, D., Ding, X., and Yao, X. (2015). Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration. The Journal of biological chemistry 290, 23766-23780.
  4. Chu, L., Huo, Y., Liu, X., Yao, P., Thomas, K., Jiang, H., Zhu, T., Zhang, G., Chaudhry, M., Adams, G., Thompson, W., Dou, Z., Jin, C., He, P., and Yao, X. (2014). The spatiotemporal dynamics of chromatin protein HP1alpha is essential for accurate chromosome segregation during cell division. The Journal of biological chemistry 289, 26249-26262.
  5. Zhu, T., Dou, Z., Qin, B., Jin, C., Wang, X., Xu, L., Wang, Z., Zhu, L., Liu, F., Gao, X., Ke, Y., Wang, Z., Aikhionbare, F., Fu, C., Ding, X., and Yao, X. (2013). Phosphorylation of microtubule-binding protein Hec1 by mitotic kinase Aurora B specifies spindle checkpoint kinase Mps1 signaling at the kinetochore. The Journal of biological chemistry 288, 36149-36159.
  6. Liu, Z., Ren, J., Cao, J., He, J., Yao, X., Jin, C., and Xue, Y. (2013). Systematic analysis of the Plk-mediated phosphoregulation in eukaryotes. Briefings in bioinformatics 14, 344-360.
  7. Tao, Y., Jin, C., Li, X., Qi, S., Chu, L., Niu, L., Yao, X., and Teng, M. (2012). The structure of the FANCM-MHF complex reveals physical features for functional assembly. Nature communications 3, 782.
  8. Zhao, L., Jin, C., Chu, Y., Varghese, C., Hua, S., Yan, F., Miao, Y., Liu, J., Mann, D., Ding, X., Zhang, J., Wang, Z., Dou, Z., and Yao, X. (2010). Dimerization of CPAP orchestrates centrosome cohesion plasticity. The Journal of biological chemistry 285, 2488-2497.
  9. Xue, Y., Liu, Z., Gao, X., Jin, C., Wen, L., Yao, X., and Ren, J. (2010). GPS-SNO: computational prediction of protein S-nitrosylation sites with a modified GPS algorithm. PloS one 5, e11290.
  10. Xue, Y., Gao, X., Cao, J., Liu, Z., Jin, C., Wen, L., Yao, X., and Ren, J. (2010). A summary of computational resources for protein phosphorylation. Current protein & peptide science 11, 485-496.
  11. Ren, J., Liu, Z., Gao, X., Jin, C., Ye, M., Zou, H., Wen, L., Zhang, Z., Xue, Y., and Yao, X. (2010). MiCroKit 3.0: an integrated database of midbody, centrosome and kinetochore. Nucleic acids research 38, D155-160.
  12. Ren, J., Jiang, C., Gao, X., Liu, Z., Yuan, Z., Jin, C., Wen, L., Zhang, Z., Xue, Y., and Yao, X. (2010). PhosSNP for systematic analysis of genetic polymorphisms that influence protein phosphorylation. Molecular & cellular proteomics : MCP 9, 623-634.
  13. Yuan, K., Li, N., Jiang, K., Zhu, T., Huo, Y., Wang, C., Lu, J., Shaw, A., Thomas, K., Zhang, J., Mann, D., Liao, J., Jin, C., and Yao, X. (2009). PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation. The Journal of biological chemistry 284, 23072-23082.
  14. Yuan, K., Li, N., Huo, Y., Yan, F., Yang, Y., Ward, T., Jin, C., and Yao, X. (2009). Recruitment of separase to mitotic chromosomes is regulated by Aurora B. Cell cycle (Georgetown, Tex) 8, 1433-1443.
  15. Ren, J., Wen, L., Gao, X., Jin, C., Xue, Y., and Yao, X. (2009). DOG 1.0: illustrator of protein domain structures. Cell research 19, 271-273.
  16. Xue, Y., Ren, J., Gao, X., Jin, C., Wen, L., and Yao, X. (2008). GPS 2.0, a tool to predict kinase-specific phosphorylation sites in hierarchy. Molecular & cellular proteomics : MCP 7, 1598-1608.
  17. Ren, J., Wen, L., Gao, X., Jin, C., Xue, Y., and Yao, X. (2008). CSS-Palm 2.0: an updated software for palmitoylation sites prediction. Protein engineering, design & selection : PEDS 21, 639-644.
  18. Gao, X., Jin, C., Xue, Y., and Yao, X. (2008). Computational analyses of TBC protein family in eukaryotes. Protein and peptide letters 15, 505-509.
  19. Gao, X., Jin, C., Ren, J., Yao, X., and Xue, Y. (2008). Proteome-wide prediction of PKA phosphorylation sites in eukaryotic kingdom. Genomics 92, 457-463.
  20. Zhang, N., Liu, J., Ding, X., Aikhionbare, F., Jin, C., and Yao, X. (2007). FBXL5 interacts with p150Glued and regulates its ubiquitination. Biochemical and biophysical research communications 359, 34-39.
  21. Liu, D., Ding, X., Du, J., Cai, X., Huang, Y., Ward, T., Shaw, A., Yang, Y., Hu, R., Jin, C., and Yao, X. (2007). Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment. The Journal of biological chemistry 282, 21415-21424.
  22. Jin, C., Cai, X., Ma, H., Xue, Y., Yao, J., and Yao, X. (2007). An efficient site-directed mutagenesis method for ColE1-type ori plasmid. Analytical biochemistry 363, 151-153.
  23. Xue, Y., Chen, H., Jin, C., Sun, Z., and Yao, X. (2006). NBA-Palm: prediction of palmitoylation site implemented in Naive Bayes algorithm. BMC bioinformatics 7, 458.
  24. Liu, D., Zhang, N., Du, J., Cai, X., Zhu, M., Jin, C., Dou, Z., Feng, C., Yang, Y., Liu, L., Takeyasu, K., Xie, W., and Yao, X. (2006). Interaction of Skp1 with CENP-E at the midbody is essential for cytokinesis. Biochemical and biophysical research communications 345, 394-402.
  25. Li, A., Xue, Y., Jin, C., Wang, M., and Yao, X. (2006). Prediction of Nepsilon-acetylation on internal lysines implemented in Bayesian Discriminant Method. Biochemical and biophysical research communications 350, 818-824.
  26. Jin, C., Ge, L., Ding, X., Chen, Y., Zhu, H., Ward, T., Wu, F., Cao, X., Wang, Q., and Yao, X. (2006). PKA-mediated protein phosphorylation regulates ezrin-WWOX interaction. Biochemical and biophysical research communications 341, 784-791.
  27. Jin, C., Zhang, Y., Zhu, H., Ahmed, K., Fu, C., and Yao, X. (2005). Human Yip1A specifies the localization of Yif1 to the Golgi apparatus. Biochemical and biophysical research communications 334, 16-22.